While I agree that the refs screwed this up for Aaron Donald and could have prevented all this from happening, the stats don't bear out that the Rams are being picked on penalty-wise more than the other teams.
The Rams are tied for 23d with the Eagles and Bengals with 55 penalties called against them. Interestingly enough, the Chiefs get penalized more than any other team with 84 penalties called against them. The Titans have the least amount with 41 and of course the Patriots are 31st with 47.
The Chiefs have 12 offensive holding penalties, while the Rams have 6. The Chiefs also lead the league with 14 defensive holding calls. The Rams are tied for second with 6 roughing the passer penalties.
https://www.footballdb.com/stats/penalties.html?sort=numpen