Hire good, patient, flexible minded coaches for every position on offense, who all "buy in" to the system you want to run. Make sure they are also good teachers, and shapers of young men. In free agency, and the draft, take the best players available, who you can fit inside your salary cap without handcuffing yourself.
If you think a franchise QB comes along the way, you get him, because they are few and far between. Secure a solid backup QB.
All things being equal, which they are not, build from the inside out, but the truth is, you will only always be as good as your coaching, player management, and all 53, but particularly your dressed 46, believing in, and playing hard for your staff.
Oh, I almost forgot. Have a good relationship with the commissioner, and push the boundaries of gaining an advantage whenever you can.