As we are all aware, the Rams under Sean McVay play few, if any, starters in preseason games. This approach has worked well, as the Rams are 5-0 under McVay in season openers, and have amassed a 16-4 record in the first four games over that span.
The Bills are taking a different approach:
View: https://twitter.com/BuffRumblings/status/1560589939041075200
So, how might this impact opening day?
Certainly, if the Bills suffer any injuries to starters in their game against the Broncos, there will be cause for criticism.
Apart from that issue, though, which is the better approach?
I'd say it depends on the team. I'd say that, for teams like the Rams and the Bills, who are returning their key starters on teams that are deemed contenders, the Rams' approach makes more sense. A team with a new QB, new system, or significant roster turnover might need more preseason reps. Teams like the Rams and the Bills can hit the ground running.
So... are the Bills making a mistake? Time will tell.