Obviously there can be injuries. The Rams have improved their OL depth, but more needs to be done, though you can never do enough. Otherwise I'd expect improvement, given more experience including of McVay, and of course the addition of Cooks. Also, with improvements on defense, I expect the Rams to get the ball back more quickly, which should help the offense - more plays, and the opposing defenses will be more tired.
Even without Donald, I expected the team to be a serious Super Bowl threat, With him this year, even more so.