This is a huge loss for them. Our defense is fast and hits, it swarms. Carlos Hyde is a hitter of a RB with a really nice combination of elusiveness and lateral movement. Assuming Bush is the next man up, he doesn't bring the power needed to offset our speed on defense. This Niner offense will be in the hands of Kap more because of the loss of Hyde. Third and mediums happen less frequently and that plays strongly into our hand with our pass rush and blitzing.
I'm not overlooking the Niners, but we win this one convincingly based off of the good situations our defense presents our offense.