THIS^
I'd put a spy on him and really keep your pass rushing lanes to force him to throw from the pocket and his effectiveness suffers greatly. It's when he has open space in front of him and can tuck the ball and run that he can rip off some big yardage but, as was quoted, he is most dangerous to me when he is running around like a chicken with his head cut off, extending plays, and finding someone open deep. That also forces the DBs to stay with their guys and not get tempted to come up and try to get him until he is past the LOS.
SF still has a good D and this might be a game where Gurley doesn't run for 100000 yards and carry the offense on his back. The O might actually have to contribute. What SF seems to be lacking that would really hurt us in the past, is losing guys like Gore who could gash you inside and take seemingly benign plays and cut back for big gains. I think their rushing attack is very different this season. SFs DTs always seemed to get penetration in the past too.
It is a fragile team that if we play a cleaner game can handle but my biggest worries are taking teams that can almost quit during a game and give them life by poor plays. Get up on them fast and keep going. That's what pissed me off the most about the Cleveland game. For being totally dominated they were one holding call on a long pass taken away from being at the door step of a 10-6 (?) game at the time.