IMO their secondary is their Achilles heel. They will have a hard time covering Kupp and Robinson. I think McVay might go with 12 personnel. Use Hopkins to chip Miller then get into the route. Also, it would probably allow them to play strictly zone, i.e. outside and inside zone in their run blocking. If the Rams can start running on them their secondary won't hold up against Kupp, Robinson and Higbee. I see them playing zone most of the game, and Kupp and Robinson should eat it up.
The key for the Rams is to play a clean game. That's the only way I see them losing.