I usually lose the first game on purpose so I have top pick in waivers. I've won the past two years in a row partially due to the waiver wire pickups I've taken. Last year it got me Alfred Morris.
I'm not sure how your league works but if you don't want to do that or if it's hard to get into your playoffs, I'd go with either Johnson or Cruz. Probably Johnson since he's a RB. If you're in a PPR, Cruz makes it a little closer. I do, however, think Jackson is going to have a rebound year. I'd wait for him to prove it though before starting him.
As always, these are purely my opinions and do not reflect the opinions of ROD.com. Use at your own discretion. Use of said opinions are meant for entertainment purposes only. V3 cannot be held accountable for any outcomes(unless they're good).